Same, same … didn’t mean to suggest otherwise. That I appreciate you standing up for science and medicine is all I was meaning to convey.
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My experience, when you ask honest, curious people to question their assumptions only good things can happen
- They question their assumptions and evolve
- They stop arguing from bad information
- or -
- They are subject matter experts and teach me something I didn’t otherwise know
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Open mindedness is huge for me…
I know nothing is perfect… and I try to always ask “then what happens”?!
Like how do we get me safely off this stuff? Comparing it to taking a steroid pack and slowing dropping the dosage…
or, asking about muscle loss and we got into how much protein I need to do extra
I find you to be a very wise person. I imagine that is the upside of the twists and turns that you have lived through.
Anytime there’s a “wonder drug”, firms like the one I worked at will have their antennae up about how that drug is marketed, what warnings are on it and how the drug companies wine and dine doctors who are likely to prescribe. They’ll also start watching trendlines and tracking journal articles etc about side effects. They don’t want to be starting from scratch when people start croaking/having major complications.
Vioxx was just such a wonder drug. It was billed as “super aspirin” and over 80 million people were prescribed… and then a bunch of them started having heart attacks and Merck had to fork over $5 Billion. They had done studies and got FDA approval and it all looked on the up and up, but there was a lot of bad wood underneath the veneer. Pharma Tort lawyers will be understandably skeptical that drug companies “learned their lesson” with this wonderdrug.
My point is that with the massive popularity of such a powerful drug, it isn’t the Better Call Saul’s of the world who are tracking this.
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This is fair
I think the distinction I am making is that we have real world data on GLP-1 agonists for 20 years dating back to Byetta. This was not a weight loss drug, but after noticing that patients on it tended to lose weight, that mechanism began to be explored. I was involved in animal studies with Byetta back in 2011 (no, I was not the subject). After 20 years we have a very good idea how these medicines work and what the side effects might be. There aren’t likely to be any surprises
By comparison, Vioxx was approved in May, 1999 and by November there were already concerns regarding cardiac events with its use. It was withdrawn from the market after five years and probably would have been much sooner if not for Merck’s malice.
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That’s a very good point. I think that the litigation exposure here is likely more do the marketing than the drug, which will make for an interesting case.
There will be people who are just willfully oblivious to the side effects and think these drugs are harmless skinny shots that require no maintenance. When/If they have nasty side effects, will they get held to task for being so glib with their own health or will juries say the drugs were marketed in such a way as to impermissibly downplay risks and benefits. And if Juries side with the “victims” will courts allow that to stand or reverse the verdicts as contrary to law. It’s gonna be a juicy pot to fight over.
Wegovy already got some flack for doing this ( FDA says Novo Nordisk's TV ad for obesity pill includes 'false or misleading' claims) and that’s probably the angle I’d be looking at (unless some really bad stuff starts happening).
The thing is though cigarette smoking does cause cancer, emphysema birth defects. These are known knowns - and the tobacco companies lied about it, hired PR firms to whitewash evidence and marketed to children
GLP companies do none of that. And the side effects aren’t caused by the drug itself. The side effects are caused by the effects of the drug when users dont take proper steps to mitigate them.
When people stop eating because they’re not hungry and stop taking in the proper amount of hydration, electrolytes, and protein…. these things are going to happen. Also titration schedules are important. if a user has a responsible doctor or smart clinician, they will start with a small dose and slowly titrate up.
Thing is, too many people buy of the gray market. Start with max clinical dose, just stop eating while their hydration drops and electrolytes tank, then yes; they are going to look gaunt, have muscle loss, hair and skin issues….
That’s why what I’m trying to do is create products and a support system with transparency and coaching so if people choose to take GLP’s, they can do so in an optimum and wholistic focused way
This is also a problem with how fast society moves now and social media influencer culture. Social adoption of a drug like this happens before the infrastructure of knowledge and support can fully develop.
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You sure about that? I’m kidding…only partially. Wherever there’s THAT much money to be made, I have a jaundiced eye.
That is a noble endeavor and I support you whole heartedly
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You know there’s a pill for that
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Yeah but one of the side effects is weight gain, so I think I’ll just go blind
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% on misuse as well as a tale of caution with a “wonder drug”…. I was actually surprised my Doctor prescribed Zepbound for me as I was fully away of all the PR on line for it as well as Ozempic… but she showed me the data.
And, implored that I had to hydrate, walk daily and double my protein…. I still can’t believe I dropped 30 pounds….
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I have my app fully flushed out in HTML right now. all I have to do is deploy it to Vercel then a PWA manifest and i’ll have a live beta app. I was planning on doing that tonight, but turns out all I wanna do is lay in my room and watch the new season of From.
But on Friday, I get hernia surgery so I’ll be in bed for two weeks and I plan to finish a couple of apps i’m working on
I’m stoked to have some of yall try it out and let me know what you think
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Good luck and swift recovery bud.
This new hiatal hernia gave me a good jolt of pain today at the hiatus (how a diaphragm of a singer gets torn pisses me off) , and of course So Much Reflux. Gaviscon seems to work at night. Scrips worked better but vitamin depletion made me tired enough to fall asleep at 8pm, so offa those. Glad I don’t have the hernia location lower.
Like Chip does. He needs hernia surgery too. Looks bad. Also getting melanoma out of his back, pretty good chunk. Being old beats being dead, but it sure ain’t being young and running around Breton Village and Eastbrook and Woodland w/o a care in the world…
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lol true that. I do miss the days of everyone riding bicycles to calvin’s campus loaded up with baseball equipment
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Let’s check back in 3 to 5 years and see how a lot of these recipients are doing. I hope they are doing well.
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I’m simply Not surprised …
We suddenly feel good think we look better and then our significant other is ….
A. Just not worthy of me anymore
B. So I’ll find a hotter looking one to match my physical change
Classic exposure of a screwed up human soul…
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I actually think it’s more so the dimming of general desires. I have heard this. Which is probably why it holds so much promise for addiction management.
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