Can we have a GLP-1 conversation?

For the negative concerns (which I totally get with a new drug doing this well)…

I had another counsel session with my doc today… I’m so blessed… what’s happening with all the “bad” results is the person not properly eating…. And not walking daily…

If folks did this, there would be no muscle mass loss, hair loss etc….

Trying not to boast but both doctors are like “why can’t everyone else get it like you do”….

We discussed the exit plan as well …. When I hit (hopefully) my goal of 161 (24.9 BMI) I will taper off the dosage as you would a steroid pack… and hoping to get off it completely then and maintain my weight and BMI myself

All the best clinical research is published on TikTok

Agreed. He also looks like he may want to see a dermatologist.

But I have heard these anecdotal observations from people on them as well. :man_shrugging:

What crazy is my doctor confirmed this to a degree yesterday…

She heard this is happening but hasn’t seen any studies about it yet

Yeah, I’ve heard it too

Not sure if it is a feature or a bug. If GLP-1 reduces compulsive/addictive behavior then it is reasonable to think it might impact relationships, but mainly relationships based on compulsion/obsession which are probably not terribly healthy

Neal Shah is legitimate AFAIK but people will leech on to this video as “proof” of [something]

lol, imho you are being sort of too nicer

Most people, sadly and imho, have selfish relationships to boot…. This simply magnifies the individual and thier narcissistic souls

when their partners lose weight stop drinking too much and doing rails off the karaoke machine, they seem like totally different people

They’re just not fun anymore :face_with_tongue:

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This plays a part of it. So, in 2018 I had gastric bypass. As part of the process, you have to go through different evaluations, including speaking to a psychiatrist. The easy answer is to say this is basically a way for a bunch of doctors to stick their hands out, but it also does serve purposes. Anyways, as part of the psych evaluation, one thing they do tell you is that many couples where only one person gets the surgery, those couples seem to have a high rate of ending in divorce versus if both people get it.

The physical changes are a big deal of course, but it’s also the emotional changes. Yes, the person who loses weight may start feeling more vain and enjoy new attention they weren’t getting before. That causes issues of jealousy, etc. Another underlying reason but still just as impactful, your lifestyle changes. A LOT of social behavior is built around sharing food, sharing routines and activities. When someone makes a change, even to just start working out more, they will slowly stop hanging around people who do not and start hanging around people who do. Magnify this in intensity for how a couple is, and you can see why it now leads to divorce.

I remember an old documentary, well before weight loss surgery was mainstream, and it was documenting a woman who was 600lbs and obviously morbidly obese. The show offered to sponsor her surgery if they could document her transformation. The followed the woman pre surgery, and she talked about how hard it was to move around, how people gave her dirty looks, and how depressed she was. She has the surgery, the weight starts coming off and for the first time, she is trimming down and able to be more athletic. She starts wearing more revealing clothing, getting more attention from men, and you’d think things were turning around for her, right?

Wrong. The woman basically started turning into a massive bitch. Anyone else overweight, she treated like people treated her when she was overweight. Anyone paying attention to her now? Well, they only like her because she is skinny. Anyone who was trying to tell her she’s changed as a person? Oh, they are just jealous because now she looks good and that intimidates them. It was really surprising to see her personality totally change. In pretty short order, she basically drove everyone away from her. Now she is depressed because she is alone, and she started eating again and gained the weight back.

For those who don’t know, something similar happened with Ron Lester, aka Billy Bob from Varsity Blues. He was always cast as the fat guy for movies. He has gastric bypass, lost over 300lbs, but now couldn’t find work as an actor because he was skinny and people knew him as the fat guy. He ended up getting 14 surgeries for skin removal and eventually died from kidney failure. Before he died, he was asked if he could go back would he still do the surgery. He said he would not, he would rather die fat, happy and rich and gone out on top.

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Here’s a reasonable take on GLP-1 and mood

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Yep

Ok, I’m on Zepbound. So I can’t say anything on this Ozempic stuff

So, for the last eight weeks that I’ve been on this stuff…. I actually feel the opposite!

If you do a natural fast (remember I’ve done 3,7,10,14,22 say fasts, only water for all) your thinking is simply clearer. And I am experiencing this right now. It’s kind of cool but I also feel like I’m cheating… as I’m eating as ly doctor has told me to.

Point is I’m starting to wonder if this concoction is a better variation? I’m told it’s the most “potent” of them all; aka why I making sure every thirty days I have a face to face with my docotor to check me..

Or, there are a lot of folks doing it wrong. Like one snort of cocaine is too many and 1000 never enough shit

that’s really interesting thanks for sharing. And more evidence that these things should be approached from a mental and spiritual mindset rather than just physical

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led zeppelin GIF

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Nice…. You’d think a dude in his sixties would have seen that sooner!

:+1::backhand_index_pointing_up::clap::100:

And an Amen to boot!!

Wonder how Robert Plant kept the weight off in the 70s…

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Probably true for most things.

what is GLP-1 ?

Ozempic works by mimicking the effect of GLP-1 and so activating these GLP-1 receptors so they think they’ve received a message from naturally produced GLP-1.

This reduces cravings and appetite and so reduces food intake/calorie intake, and also reduces blood sugar levels, which can be helpful for people with diabetes, which is what it was originally approved for.

It does this in many ways. It affects our hunger hormones, leptin and ghrelin. Ghrelin tells us when we need food and makes us feel hungry. And leptin tells our body when it’s eaten enough food and takes away the feeling of hunger.

So it reduces cravings or appetite for food, while increasing the feeling we’ve eaten enough. With this it also delays the emptying of the stomach, further making someone not want to eat as much. And some people get nausea taking this, also causing them to not want to eat as much.

In a lot of people this causes weight loss, pretty simply because they’re just not eating as much.

But it also increases metabolism, the burning and use of energy in our body, which is also necessary for fat loss.

This is because, when we activate the GLP-1 receptors, we’re also lowering sugar levels and removing sugar from the blood.

Remember, this was originally created for diabetics

What I am on is stronger….

Zepbound (Tirzepatide): A single drug that mimics two hormones: GLP-1 and GIP (glucose-dependent insulinotropic polypeptide)